Regulation of neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of neuron apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G, HNRNPA2B1_S189, and SEPTIN4_S432, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron apoptotic process activity versus EIF3G in OV (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EIF3G →	-0.276	-0.034	.001	<.001	2	7
OV	HNRNPA2B1_S189 →	-0.714	-0.044	.003	.001	3	6
BRCA	SEPTIN4_S432 →	+0.506	+0.018	<.001	.001	3	6
GBM	SEPTIN4_S117 →	+0.874	+0.030	.004	<.001	3	5
GBM	CACNA2D1 →	+0.528	+0.041	.003	<.001	3	5
BRCA	RPS16 →	-0.207	-0.019	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043523 vs EIF3G — OV

Explore this scatter interactively →