Regulation of neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODC1-DT, SLC7A6, and PALD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron apoptotic process activity versus ODC1-DT in OV (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ODC1-DT →	+0.502	+0.132	.007	.001	3	3
OV	SLC7A6 →	+0.878	+0.143	.003	.001	3	2
OV	PALD1 →	+0.772	+0.114	<.001	.002	3	2
COAD	BCL11A →	+0.499	+0.131	.002	<.001	3	2
OV	MDC1 →	+1.401	+0.141	.003	.001	3	2
OV	DPY19L2P2 →	+1.061	+0.094	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043523 vs ODC1-DT — OV

Explore this scatter interactively →