Regulation of neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRGN, PCBP4, and PEX11B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRGN grouped by Regulation of neuron apoptotic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SRGN →	-4.810	-0.232	.001	<.001	3	4
URINARY_TRACT	PCBP4 →	-1.664	-0.232	<.001	<.001	3	4
BLOOD_Leukemia	PEX11B →	+0.609	+0.151	<.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	DDIT4 →	+1.663	+0.219	<.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	SERPINB5 →	+1.593	+0.213	.006	.004	3	3
URINARY_TRACT	SUSD6 →	+1.297	+0.247	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRGN by Regulation of neuron apoptotic process activity — URINARY_TRACT

Explore this box plot interactively →