"Negative regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRT1, ARID5B, and ITGA4, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of DNA damage response, signal transduction by p53 class mediator" activity versus SIRT1 in UVM (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SIRT1 →	+1.398	+0.088	<.001	<.001	3	32
TGCT	ARID5B →	+1.211	+0.052	<.001	<.001	3	30
THYM	ITGA4 →	+1.462	+0.057	<.001	<.001	3	30
DLBC	MED13L →	+1.256	+0.066	<.001	<.001	3	30
UVM	BACH1 →	+1.286	+0.086	<.001	<.001	3	30
CHOL	REL →	+0.904	+0.077	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043518 vs SIRT1 — UVM

Explore this scatter interactively →