"Negative regulation of DNA damage response, signal transduction by p53 class mediator"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of DNA damage response, signal transduction by p53 class mediator" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA8H, BRI3, and IL17D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOLGA8H grouped by "Negative regulation of DNA damage response, signal transduction by p53 class mediator"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GOLGA8H →	+1.131	+0.259	<.001	<.001	3	4
CNS	BRI3 →	-1.070	-1.291	.003	<.001	3	4
CNS	IL17D →	+1.273	+1.034	.003	.003	3	4
OESOPHAGUS	TMBIM1 →	+1.598	+0.320	.001	.002	3	3
OESOPHAGUS	KRT19 →	+5.666	+0.282	.003	.004	2	4
BREAST	EPS8L2 →	+2.429	+0.515	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOLGA8H by "Negative regulation of DNA damage response, signal transduction by p53 class mediator" activity — BLOOD_Leukemia

Explore this box plot interactively →