Negative regulation of JUN kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of JUN kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3HAV1, ARPC5, and SERPINB3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of JUN kinase activity activity versus ZC3HAV1 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZC3HAV1 →	-0.338	-0.499	<.001	.001	3	3
UCEC	ARPC5 →	+0.327	+0.123	<.001	.009	3	2
UCEC	SERPINB3 →	+1.572	+0.210	<.001	.001	3	2
UCEC	RAPGEF4 →	+0.712	+0.112	<.001	<.001	3	2
PDAC	EFL1P1 →	+0.219	+0.698	.003	.002	3	2
LUAD	UTP18 →	-0.261	-0.368	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043508 vs ZC3HAV1 — LUAD

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