Negative regulation of JUN kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of JUN kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF2, HHLA3, and TSHZ3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAF2 grouped by Negative regulation of JUN kinase activity-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRAF2 →	+0.623	+1.039	.001	.007	3	4
LUNG_NSCLC_LUAD	HHLA3 →	+1.380	+0.773	<.001	.003	3	3
CNS	TSHZ3 →	-1.097	-0.915	.004	.003	3	3
BLOOD_Lymphoma	PKD1L1 →	+1.276	+0.404	.002	.008	3	3
BLOOD_Lymphoma	TSACC →	+0.870	+0.239	<.001	.008	3	3
BLOOD_Lymphoma	ZNF529 →	+2.060	+0.404	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAF2 by Negative regulation of JUN kinase activity activity — SOFT_TISSUE

Explore this box plot interactively →