Positive regulation of JUN kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of JUN kinase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMXL1, AOX1, and DIAPH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBMXL1 grouped by Positive regulation of JUN kinase activity-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RBMXL1 →	+0.238	+0.503	.008	.004	3	5
LUNG_SCLC	AOX1 →	+0.258	+0.285	.002	.006	3	4
BONE	DIAPH2 →	+0.287	+0.457	.007	.002	3	4
LARGE_INTESTINE	RPS3 →	-0.250	-0.276	.006	.005	3	4
STOMACH	CC2D1A →	-0.345	-0.248	.009	.008	3	3
BLOOD_Leukemia	SLC6A19 →	+0.239	+0.360	.003	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBMXL1 by Positive regulation of JUN kinase activity activity — PANCREAS

Explore this box plot interactively →