Positive regulation of JUN kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of JUN kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN2, PDZD11, and TAOK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of JUN kinase activity activity versus BIN2 in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BIN2 →	+3.000	+0.782	.001	.001	3	3
BLOOD_Leukemia	PDZD11 →	-0.957	-1.101	.003	<.001	3	3
BLOOD_Leukemia	TAOK3 →	+0.946	+0.745	<.001	<.001	3	3
CNS	GRK2 →	-0.748	-0.349	.001	.007	3	3
URINARY_TRACT	COMMD6 →	+1.719	+0.406	.002	.005	3	3
LUNG_SCLC	SPDYE16 →	-0.282	-0.861	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043507 vs BIN2 — BLOOD_Leukemia

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