Mitochondrial DNA repair

Across TCGA cell cohorts, RNA activity of the Mitochondrial DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBLD, LPAR5, and PSD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PBLD grouped by Mitochondrial DNA repair-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PBLD →	-1.491	-1.530	<.001	<.001	3	4
LUNG_NSCLC_LUAD	LPAR5 →	+0.891	+0.498	.008	.007	2	5
KIDNEY	PSD3 →	+1.628	+1.361	.009	.001	3	3
LARGE_INTESTINE	SLC25A27 →	+1.454	+0.656	.002	.005	3	3
LARGE_INTESTINE	TFE3 →	-0.617	-0.562	.001	<.001	3	3
STOMACH	C11orf24 →	+0.792	+0.721	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PBLD by Mitochondrial DNA repair activity — LIVER

Explore this box plot interactively →