Mitochondrial DNA repair

Across TCGA cell cohorts, RNA activity of the Mitochondrial DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB5B, LIG3, and CYLD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA repair activity versus RAB5B in KIDNEY (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RAB5B →	+0.644	+0.252	.002	.001	3	6
BONE	LIG3 →	+1.062	+0.234	.001	<.001	3	5
SKIN	CYLD →	-0.666	-0.176	.006	<.001	3	5
STOMACH	KAT14 →	+0.984	+0.289	.007	<.001	3	5
CNS	MORC3 →	-0.602	-0.211	.001	.001	2	6
BLOOD_Lymphoma	LGALS1 →	-4.814	-0.089	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043504 vs RAB5B — KIDNEY

Explore this scatter interactively →