Regulation of muscle adaptation

Across TCGA patient cohorts, RNA activity of the Regulation of muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP10_S365, C11orf96_S399, and PRKG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle adaptation activity versus USP10_S365 in BRCA (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	USP10_S365 →	-0.417	-0.019	.004	.007	3	7
BRCA	C11orf96_S399 →	+0.587	+0.026	<.001	.005	3	6
BRCA	PRKG1 →	+0.529	+0.028	<.001	<.001	3	6
UCEC	FMNL3 →	+0.384	+0.046	<.001	<.001	3	6
BRCA	C1R →	+0.500	+0.029	<.001	<.001	3	6
BRCA	CNRIP1 →	+0.513	+0.024	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043502 vs USP10_S365 — BRCA

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