Regulation of muscle adaptation

Across TCGA patient cohorts, RNA activity of the Regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, SVEP1, and RECK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle adaptation activity versus CNRIP1 in CCRCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CNRIP1 →	+0.673	+0.175	.001	.007	3	7
HNSC	SVEP1 →	+0.844	+0.271	<.001	<.001	3	7
UCEC	RECK →	+0.719	+0.164	<.001	.002	3	7
UCEC	ZCCHC24 →	+0.955	+0.194	<.001	<.001	3	7
UCEC	FBN1 →	+1.089	+0.229	<.001	<.001	3	7
UCEC	DIPK2B →	+0.575	+0.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043502 vs CNRIP1 — CCRCC

Explore this scatter interactively →