Regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL2, CYB5D1, and ARHGAP35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PODXL2 grouped by Regulation of muscle adaptation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PODXL2 →	+3.591	+1.491	.009	.002	3	4
BLOOD_Myeloma	CYB5D1 →	+1.130	+1.201	.001	.003	2	5
STOMACH	ARHGAP35 →	-0.837	-1.154	.004	.004	3	4
BLOOD_Leukemia	SARM1 →	+1.225	+1.352	.001	<.001	3	4
LIVER	SHBG →	+0.672	+1.439	.004	<.001	3	3
LIVER	GMPR →	-2.131	-1.249	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PODXL2 by Regulation of muscle adaptation activity — BONE

Explore this box plot interactively →