Regulation of muscle adaptation

Across TCGA cell cohorts, RNA activity of the Regulation of muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEXN, TRIM16, and CHN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle adaptation activity versus NEXN in LUNG_NSCLC_LUAD (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NEXN →	-2.108	-0.169	<.001	.003	3	5
URINARY_TRACT	TRIM16 →	+1.818	+0.236	.003	.002	3	5
BLOOD_Myeloma	CHN1 →	-1.960	-0.372	<.001	<.001	3	4
BLOOD_Myeloma	PIAS3 →	-1.131	-0.294	<.001	.004	3	4
PANCREAS	NIBAN1 →	-2.208	-0.174	<.001	<.001	3	4
CNS	BTN1A1 →	-0.016	-0.175	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043502 vs NEXN — LUNG_NSCLC_LUAD

Explore this scatter interactively →