Skeletal muscle adaptation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTC21B, BSG, and TSHZ1_T852, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle adaptation activity versus TTC21B in BRCA (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTC21B →	-0.249	-0.048	.003	.002	3	6
BRCA	BSG →	+0.309	+0.036	.008	.007	3	6
BRCA	TSHZ1_T852 →	-0.542	-0.052	<.001	.001	3	5
BRCA	CROCC →	-0.301	-0.047	.002	.005	3	5
PDAC	CSE1L →	+0.247	+0.081	.002	<.001	3	5
BRCA	FOSL2 →	+0.474	+0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043501 vs TTC21B — BRCA

Explore this scatter interactively →