Skeletal muscle adaptation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPT, MRGBP, and F2RL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle adaptation activity versus DPT in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DPT →	+1.271	+1.457	.001	<.001	3	4
PDAC	MRGBP →	-0.245	-0.454	.007	.002	3	4
HNSC	F2RL2 →	+0.833	+0.906	.007	.008	2	4
OV	SUB1P1 →	-0.785	-0.807	.003	.007	3	3
PDAC	FAM83D →	-0.518	-0.875	.002	<.001	3	3
PDAC	CENPI →	-0.296	-0.360	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043501 vs DPT — HNSC

Explore this scatter interactively →