Skeletal muscle adaptation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA3, RAB32, and C19orf48, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCA3 grouped by Skeletal muscle adaptation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ABCA3 →	-1.839	-0.572	<.001	<.001	3	4
LUNG_SCLC	RAB32 →	+3.946	+1.582	<.001	<.001	3	4
OVARY	C19orf48 →	-0.860	-1.196	<.001	.004	3	3
OVARY	RPS17 →	-0.793	-1.155	.001	.001	3	3
OVARY	DNAAF4 →	+0.809	+1.344	.006	.001	3	3
LUNG_NSCLC_LUAD	FNDC11 →	+0.778	+0.727	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCA3 by Skeletal muscle adaptation activity — OESOPHAGUS

Explore this box plot interactively →