Muscle adaptation

Across TCGA patient cohorts, RNA activity of the Muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S854, SRRM2_S1424, and VIM_S72, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle adaptation activity versus SYNPO_S854 in CCRCC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SYNPO_S854 →	+0.492	+0.023	<.001	<.001	3	6
BRCA	SRRM2_S1424 →	-0.681	-0.020	.001	.006	3	5
BRCA	VIM_S72 →	+0.592	+0.025	<.001	<.001	3	5
UCEC	HSPB1_S98 →	+0.338	+0.028	.003	.001	3	5
BRCA	ASAP1 →	+0.155	+0.023	.005	<.001	3	5
BRCA	RSU1 →	+0.463	+0.043	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043500 vs SYNPO_S854 — CCRCC

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