Muscle adaptation

Across TCGA patient cohorts, RNA activity of the Muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL12, TCF4, and SPARCL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle adaptation activity versus CXCL12 in UCEC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCL12 →	+1.101	+0.164	.003	.003	3	6
BRCA	TCF4 →	+0.597	+0.233	.002	.001	3	6
HNSC	SPARCL1 →	+1.079	+0.397	<.001	.002	3	6
HNSC	JAM2 →	+0.589	+0.361	.001	.002	3	6
GBM	SRPX2 →	+1.015	+0.170	<.001	<.001	3	5
LUAD	PDLIM2 →	+0.427	+0.185	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043500 vs CXCL12 — UCEC

Explore this scatter interactively →