Muscle adaptation

Across TCGA cell cohorts, RNA activity of the Muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSN, MAP3K1, and TTC26, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle adaptation activity versus GSN in BLOOD_Leukemia (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSN →	+1.822	+0.360	.003	.004	3	6
OESOPHAGUS	MAP3K1 →	+1.337	+1.048	.001	.007	3	5
OESOPHAGUS	TTC26 →	+0.974	+1.144	.003	<.001	3	4
OESOPHAGUS	MSH6 →	+0.882	+1.109	.005	<.001	3	4
BONE	CPNE7 →	-4.380	-0.406	.006	.005	2	4
LARGE_INTESTINE	GJB2 →	-1.480	-0.561	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043500 vs GSN — BLOOD_Leukemia

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