Phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF8, CLEC2B, and KHDRBS2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus TNFSF8 in COAD (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TNFSF8 →	+0.542	+0.503	.008	.006	3	1
COAD	CLEC2B →	+0.821	+0.437	<.001	.007	3	1
COAD	KHDRBS2 →	+0.110	+0.522	<.001	.005	3	1
COAD	CCR2 →	+0.837	+0.507	.001	.006	3	1
COAD	TNNI2 →	+0.771	+0.556	<.001	.003	3	1
COAD	BMP6 →	+0.538	+0.521	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043491 vs TNFSF8 — COAD

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