Phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMC3IP, NUDT2, and GPD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus PSMC3IP in SKIN (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PSMC3IP →	-0.708	-1.016	.007	.005	3	5
LUNG_SCLC	NUDT2 →	-1.032	-0.779	.004	.006	3	4
SKIN	GPD2 →	-0.802	-1.336	<.001	<.001	3	4
SKIN	SLC25A19 →	-0.773	-1.012	.008	.004	3	4
BONE	CYB5RL →	-0.899	-1.234	.003	.001	3	4
URINARY_TRACT	EGFR →	+1.255	+1.279	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043491 vs PSMC3IP — SKIN

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