Phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBCA, ACAT2, and NEDD8, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus TBCA in URINARY_TRACT (Pearson r = -0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TBCA →	-2.493	-1.191	<.001	<.001	3	10
SKIN	ACAT2 →	-1.277	-0.807	.005	.004	3	10
URINARY_TRACT	NEDD8 →	-2.065	-1.494	.002	<.001	3	10
SKIN	GART →	-1.006	-1.098	<.001	<.001	3	10
URINARY_TRACT	PEBP1 →	-2.828	-1.464	.001	<.001	3	9
BREAST	OXSR1 →	-0.733	-0.899	.006	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043491 vs TBCA — URINARY_TRACT

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