RNA stabilization

Across TCGA patient cohorts, RNA activity of the RNA stabilization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB32, OTULINL, and AIF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA stabilization activity versus RAB32 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAB32 →	+0.361	+0.026	<.001	.004	3	5
LSCC	OTULINL →	+0.289	+0.031	<.001	<.001	3	5
GBM	AIF1 →	+0.496	+0.029	<.001	<.001	3	4
GBM	FERMT3 →	+0.573	+0.050	<.001	<.001	3	4
LSCC	ARHGAP32_S682 →	-0.454	-0.035	.004	.001	3	4
GBM	ARHGAP45_S592 →	+0.606	+0.039	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043489 vs RAB32 — OV

Explore this scatter interactively →