RNA stabilization

Across TCGA cell cohorts, RNA activity of the RNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEPRO, CCDC191, and NUP93, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEPRO grouped by RNA stabilization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NEPRO →	-0.530	-0.105	<.001	.007	3	4
LUNG_NSCLC_LUAD	CCDC191 →	-0.413	-0.103	.008	<.001	3	4
CNS	NUP93 →	-0.414	-0.127	.003	.005	3	4
BLOOD_Myeloma	PLA2G4A →	+2.874	+0.139	.006	.001	3	4
BLOOD_Myeloma	KCNE3 →	+0.144	+0.159	.009	.006	3	4
PANCREAS	ST13 →	-0.651	-0.163	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEPRO by RNA stabilization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →