RNA stabilization

Across TCGA cell cohorts, RNA activity of the RNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAD, NPM3, and CDK4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA stabilization activity versus CAD in LIVER (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CAD →	+1.227	+0.288	.009	.003	2	7
OVARY	NPM3 →	+0.976	+0.208	<.001	<.001	3	6
OVARY	CDK4 →	+0.748	+0.247	<.001	<.001	3	6
PANCREAS	RPIA →	+0.662	+0.184	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	TIMM9 →	+1.057	+0.195	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	KPNA3 →	+1.189	+0.271	<.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043489 vs CAD — LIVER

Explore this scatter interactively →