Regulation of RNA splicing

Across TCGA patient cohorts, RNA activity of the Regulation of RNA splicing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL26, RPL4, and EEF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of RNA splicing activity versus RPL26 in GBM (Pearson r = -0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL26 →	-0.862	-0.067	<.001	.001	3	6
GBM	RPL4 →	-0.326	-0.035	.002	.005	2	7
HNSC	EEF2 →	-0.228	-0.077	<.001	.001	3	6
HNSC	GABPA →	+0.207	+0.052	<.001	.004	3	6
LUAD	ARID4B →	+0.191	+0.034	<.001	<.001	3	6
LSCC	GATAD2B_S334 →	+0.537	+0.040	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043484 vs RPL26 — GBM

Explore this scatter interactively →