Regulation of RNA splicing

Across TCGA cell cohorts, RNA activity of the Regulation of RNA splicing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF24, SIRT3, and UCK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF24 grouped by Regulation of RNA splicing-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RNF24 →	+1.036	+0.166	.001	.008	3	6
LUNG_NSCLC_LUSC	SIRT3 →	+0.787	+0.209	.003	.001	3	6
BLOOD_Leukemia	UCK2 →	-0.521	-0.193	.002	.002	3	5
BREAST	PCBP4 →	+1.222	+0.127	.001	<.001	3	5
LUNG_NSCLC_LUAD	RPL36 →	+0.495	+0.148	.003	.008	3	5
UPPER_AERODIGESTIVE_TRACT	AHRR →	+1.564	+0.130	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF24 by Regulation of RNA splicing activity — CNS

Explore this box plot interactively →