Pigmentation

Across TCGA patient cohorts, RNA activity of the Pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, TTK, and CENPA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigmentation activity versus NUF2 in LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NUF2 →	-1.116	-0.821	<.001	<.001	3	7
BRCA	TTK →	-1.143	-0.879	<.001	<.001	3	6
UCEC	CENPA →	-1.352	-1.589	<.001	<.001	3	6
UCEC	NCAPH →	-0.592	-0.932	.008	.005	3	6
LUAD	HJURP →	-0.945	-0.829	.002	<.001	3	6
LUAD	ATAD2 →	-0.787	-0.863	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043473 vs NUF2 — LUAD

Explore this scatter interactively →