Pigmentation

Across TCGA cell cohorts, RNA activity of the Pigmentation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC10, HSD3B2, and XPO1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANAPC10 grouped by Pigmentation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ANAPC10 →	+0.238	+0.214	<.001	.003	3	3
OVARY	HSD3B2 →	+0.173	+0.742	.004	.006	3	3
URINARY_TRACT	XPO1 →	-0.558	-0.335	.004	.001	3	2
KIDNEY	MOCS3 →	+0.285	+1.615	.005	.003	3	2
SOFT_TISSUE	TMPRSS15 →	-0.675	-0.426	.005	.003	2	3
OESOPHAGUS	NAGK →	+0.143	+0.785	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANAPC10 by Pigmentation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →