Regulation of carbohydrate catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of carbohydrate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLIN2, SERBP1, and SKAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate catabolic process activity versus PLIN2 in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLIN2 →	+0.429	+0.019	.001	.003	3	5
GBM	SERBP1 →	-0.181	-0.024	<.001	.004	2	5
GBM	SKAP2 →	+0.803	+0.051	<.001	<.001	3	4
GBM	ACSL1 →	+0.565	+0.036	<.001	<.001	3	4
LSCC	ACSL5 →	+0.612	+0.046	<.001	<.001	3	4
GBM	TRAPPC12_S182 →	+0.584	+0.047	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043470 vs PLIN2 — COAD

Explore this scatter interactively →