Regulation of carbohydrate catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of carbohydrate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A4, LDHAL6EP, and ETFDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate catabolic process activity versus SLC4A4 in PDAC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A4 →	+1.728	+0.512	<.001	<.001	3	6
PDAC	LDHAL6EP →	+1.332	+0.473	<.001	<.001	3	5
CCRCC	ETFDH →	+0.566	+0.349	<.001	.005	3	4
PDAC	ERVE-1 →	+1.180	+0.428	<.001	<.001	3	4
BRCA	EGFL6 →	-1.107	-0.268	<.001	.002	3	4
BRCA	COL11A1 →	-1.700	-0.345	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043470 vs SLC4A4 — PDAC

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