Regulation of carbohydrate catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of carbohydrate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOB1, PSMB6, and PCGF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOB1 grouped by Regulation of carbohydrate catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NOB1 →	-0.830	-0.265	.008	<.001	2	5
UPPER_AERODIGESTIVE_TRACT	PSMB6 →	-1.210	-0.256	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PCGF6 →	-0.986	-0.263	.009	.001	3	4
BLOOD_Myeloma	BTN2A2 →	+2.035	+0.313	.004	.002	3	4
STOMACH	S1PR3 →	+1.555	+0.208	.001	.004	3	4
STOMACH	S1PR2 →	+0.975	+0.311	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOB1 by Regulation of carbohydrate catabolic process activity — KIDNEY

Explore this box plot interactively →