Regulation of carbohydrate catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of carbohydrate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACTIN, RPTOR, and ZBTB7A, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate catabolic process activity versus CACTIN in SOFT_TISSUE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CACTIN →	+0.807	+0.057	<.001	<.001	3	13
SOFT_TISSUE	RPTOR →	+0.851	+0.056	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	ZBTB7A →	+1.098	+0.092	<.001	<.001	3	12
SKIN	PIP5K1C →	+1.109	+0.082	<.001	<.001	3	12
LIVER	MYH9 →	+1.333	+0.042	.004	.004	3	12
SKIN	SBF1 →	+0.862	+0.052	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043470 vs CACTIN — SOFT_TISSUE

Explore this scatter interactively →