Regulation of carbohydrate catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of carbohydrate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL1, CBSL, and ZNF311, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate catabolic process activity versus UCHL1 in LUNG_NSCLC_LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UCHL1 →	+3.633	+0.548	<.001	<.001	3	5
BLOOD_Leukemia	CBSL →	+1.332	+0.357	.005	.009	3	4
SKIN	ZNF311 →	+0.932	+0.920	.006	.003	3	3
KIDNEY	SERPINA3 →	+0.996	+0.196	<.001	<.001	3	3
SOFT_TISSUE	SLC25A14 →	-0.690	-0.158	.002	.009	2	4
KIDNEY	CSPG5 →	+1.508	+0.215	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043470 vs UCHL1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →