Regulation of generation of precursor metabolites and energy

Across TCGA patient cohorts, RNA activity of the Regulation of generation of precursor metabolites and energy pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM25, TMEM42, and LINC00324, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of generation of precursor metabolites and energy activity versus TMEM25 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TMEM25 →	+0.588	+0.124	.006	.003	3	3
BRCA	TMEM42 →	+0.499	+0.172	<.001	<.001	3	3
BRCA	LINC00324 →	+0.576	+0.157	<.001	<.001	3	3
OV	SPECC1L →	+0.511	+0.118	.001	<.001	3	2
OV	DDX17 →	+0.793	+0.148	<.001	<.001	3	2
BRCA	CBX7 →	+0.588	+0.182	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043467 vs TMEM25 — OV

Explore this scatter interactively →