Regulation of generation of precursor metabolites and energy

Across TCGA cell cohorts, RNA activity of the Regulation of generation of precursor metabolites and energy pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI6, ETV4, and MRPL28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFI6 grouped by Regulation of generation of precursor metabolites and energy-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IFI6 →	+2.893	+0.142	.001	.002	3	5
KIDNEY	ETV4 →	-1.628	-0.178	<.001	.001	3	4
KIDNEY	MRPL28 →	-0.552	-0.229	.005	.007	3	4
BLOOD_Leukemia	DHDH →	+0.823	+0.179	.006	.002	3	4
BLOOD_Leukemia	COX7B →	-1.089	-0.291	<.001	<.001	3	4
PANCREAS	TIMM8B →	-0.905	-0.171	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFI6 by Regulation of generation of precursor metabolites and energy activity — OESOPHAGUS

Explore this box plot interactively →