Regulation of generation of precursor metabolites and energy

Across TCGA cell cohorts, RNA activity of the Regulation of generation of precursor metabolites and energy pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS4B, TOM1L2, and RHBDL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of generation of precursor metabolites and energy activity versus VPS4B in URINARY_TRACT (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	VPS4B →	-0.637	-0.284	.002	.008	3	6
LUNG_SCLC	TOM1L2 →	-0.777	-0.109	.004	.003	3	6
URINARY_TRACT	RHBDL2 →	-3.899	-0.193	<.001	.002	3	5
OESOPHAGUS	TBC1D8B →	-1.024	-0.245	.003	.003	3	5
LUNG_NSCLC_LUAD	RMDN3 →	-0.667	-0.155	.001	.001	3	5
SKIN	SECISBP2L →	-0.758	-0.128	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043467 vs VPS4B — URINARY_TRACT

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