Regulation of ATP-dependent activity

Across TCGA patient cohorts, RNA activity of the Regulation of ATP-dependent activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MIOS, PPP4R3A, and IPO9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP-dependent activity activity versus MIOS in LSCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MIOS →	-0.130	-0.033	<.001	<.001	3	6
BRCA	PPP4R3A →	+0.230	+0.021	<.001	.001	3	5
LUAD	IPO9 →	+0.199	+0.032	<.001	<.001	3	5
CCRCC	CERT1 →	-0.242	-0.033	<.001	<.001	3	5
UCEC	CDC73 →	+0.209	+0.055	<.001	.001	3	5
UCEC	PARP1 →	+0.311	+0.060	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043462 vs MIOS — LSCC

Explore this scatter interactively →