Regulation of ATP-dependent activity

Across TCGA cell cohorts, RNA activity of the Regulation of ATP-dependent activity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27L, SUPT5H, and CCDC121, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS27L grouped by Regulation of ATP-dependent activity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPS27L →	-1.206	-0.263	.002	.006	3	4
LIVER	SUPT5H →	+0.617	+0.241	.004	.001	3	4
BLOOD_Lymphoma	CCDC121 →	-1.067	-0.401	.001	.002	3	3
BLOOD_Lymphoma	POLQ →	+0.886	+0.307	.005	.003	3	3
SKIN	ZMAT3 →	-0.915	-0.478	.001	.009	2	4
URINARY_TRACT	NR2C1 →	-0.730	-0.369	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS27L by Regulation of ATP-dependent activity activity — OVARY

Explore this box plot interactively →