Regulation of ATP-dependent activity

Across TCGA cell cohorts, RNA activity of the Regulation of ATP-dependent activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2S3, THBS4, and LSM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP-dependent activity activity versus EIF2S3 in BLOOD_Myeloma (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EIF2S3 →	+0.517	+0.112	.004	.005	3	5
LUNG_SCLC	THBS4 →	+1.013	+0.112	.005	.003	2	6
BLOOD_Leukemia	LSM2 →	+0.358	+0.184	.009	<.001	3	5
SKIN	HPGD →	-1.735	-0.182	.001	.006	3	4
SKIN	SLC9A7 →	+1.819	+0.192	<.001	<.001	3	4
LUNG_NSCLC_LUSC	KALRN →	-1.470	-0.206	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043462 vs EIF2S3 — BLOOD_Myeloma

Explore this scatter interactively →