Regulation of pentose-phosphate shunt

Across TCGA patient cohorts, RNA activity of the Regulation of pentose-phosphate shunt pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTOR, TIGAR, and ETF1, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pentose-phosphate shunt activity versus MTOR in UVM (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	MTOR →	+1.125	+0.081	<.001	<.001	3	31
UVM	TIGAR →	+1.400	+0.096	<.001	<.001	3	31
UVM	ETF1 →	+0.985	+0.070	<.001	<.001	3	30
LAML	SLC36A1 →	+1.050	+0.075	<.001	<.001	3	29
DLBC	NIPA2 →	+1.191	+0.064	<.001	<.001	3	29
ACC	GNA12 →	+0.861	+0.046	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043456 vs MTOR — UVM

Explore this scatter interactively →