Regulation of pentose-phosphate shunt

Across TCGA patient cohorts, RNA activity of the Regulation of pentose-phosphate shunt pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOC5, TP53_S315, and RFC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pentose-phosphate shunt activity versus THOC5 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THOC5 →	+0.161	+0.034	.003	.009	3	5
LSCC	TP53_S315 →	+1.197	+0.071	<.001	<.001	3	4
BRCA	RFC2 →	+0.246	+0.038	<.001	.001	3	4
BRCA	ZC3H13 →	+0.261	+0.041	.002	.004	3	4
GBM	MTERF4 →	+0.502	+0.053	<.001	<.001	3	4
BRCA	FUS →	+0.391	+0.043	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043456 vs THOC5 — BRCA

Explore this scatter interactively →