Regulation of pentose-phosphate shunt

Across TCGA patient cohorts, RNA activity of the Regulation of pentose-phosphate shunt pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD5, RPL17P22, and C1GALT1P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pentose-phosphate shunt activity versus MFSD5 in BRCA (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MFSD5 →	-0.279	-0.129	.003	.001	3	3
CCRCC	RPL17P22 →	+0.546	+0.718	.008	<.001	3	3
CCRCC	C1GALT1P2 →	+0.697	+0.998	.009	<.001	3	3
LUAD	MEIOSIN →	-0.067	-0.302	.002	.001	3	3
GBM	CDS2 →	-0.350	-0.807	.007	.003	3	3
PDAC	PRND →	-0.456	-0.204	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043456 vs MFSD5 — BRCA

Explore this scatter interactively →