Regulation of pentose-phosphate shunt

Across TCGA cell cohorts, RNA activity of the Regulation of pentose-phosphate shunt pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F7, PARN, and GNS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, F7 grouped by Regulation of pentose-phosphate shunt-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	F7 →	+0.186	+0.904	.003	.003	3	4
BREAST	PARN →	-0.209	-0.707	.003	.005	3	3
BLOOD_Leukemia	GNS →	-0.447	-0.689	.004	.007	3	3
BLOOD_Leukemia	ALDH9A1 →	+0.442	+0.628	.001	.005	3	3
LUNG_NSCLC_LUAD	NME2 →	+0.290	+1.291	.007	.003	3	3
LUNG_NSCLC_LUAD	MTO1 →	+0.165	+1.164	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

F7 by Regulation of pentose-phosphate shunt activity — BREAST

Explore this box plot interactively →