Regulation of pentose-phosphate shunt

Across TCGA cell cohorts, RNA activity of the Regulation of pentose-phosphate shunt pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SARAF, HSD17B6, and SLC25A19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pentose-phosphate shunt activity versus SARAF in CNS (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SARAF →	-1.331	-1.591	.002	.001	3	4
BLOOD_Lymphoma	HSD17B6 →	+0.676	+0.843	.006	.009	3	4
LARGE_INTESTINE	SLC25A19 →	+0.710	+0.993	.008	.001	3	3
LARGE_INTESTINE	MRPL39 →	+0.512	+0.669	.007	.007	3	3
CNS	NACA →	+0.818	+1.262	.007	.003	3	3
CNS	ABCC3 →	-2.626	-0.986	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043456 vs SARAF — CNS

Explore this scatter interactively →