Regulation of skeletal muscle tissue regeneration

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN4, PRELP, and LAMA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle tissue regeneration activity versus SEPTIN4 in CCRCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN4 →	+0.670	+0.732	<.001	<.001	3	5
CCRCC	PRELP →	+1.281	+0.593	<.001	<.001	3	5
CCRCC	LAMA2 →	+0.851	+0.676	<.001	<.001	3	5
CCRCC	CPED1 →	+0.970	+1.134	<.001	<.001	3	4
GBM	CRISPLD1 →	+0.904	+0.481	.005	.004	3	4
PDAC	CNKSR2 →	+0.305	+0.500	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043416 vs SEPTIN4 — CCRCC

Explore this scatter interactively →