Positive regulation of skeletal muscle tissue regeneration

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN2, PSAT1, and LY6D, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of skeletal muscle tissue regeneration activity versus SESN2 in OESOPHAGUS (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SESN2 →	+1.959	+1.656	.008	<.001	3	3
OESOPHAGUS	PSAT1 →	+2.643	+1.618	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	LY6D →	-4.820	-1.170	<.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	ARVCF →	+2.066	+1.412	.007	.001	3	3
LUNG_NSCLC_LUAD	TLL2 →	-0.458	-1.662	<.001	<.001	3	2
OESOPHAGUS	MPZL1 →	+1.213	+1.666	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043415 vs SESN2 — OESOPHAGUS

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