Macromolecule methylation

Across TCGA patient cohorts, RNA activity of the Macromolecule methylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM28, BRD8, and HDAC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macromolecule methylation activity versus TRIM28 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM28 →	+0.355	+0.030	<.001	<.001	3	7
LSCC	BRD8 →	+0.366	+0.042	<.001	<.001	3	7
HNSC	HDAC2 →	+0.351	+0.071	<.001	.001	3	7
HNSC	HNRNPU →	+0.235	+0.057	<.001	.004	3	7
LSCC	NONO →	+0.245	+0.036	<.001	<.001	3	7
HNSC	PHF3 →	+0.319	+0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043414 vs TRIM28 — LSCC

Explore this scatter interactively →